Methionine-enkephalin and morphine: amount ejected microiontophoretically.

D A Hosford; H J Haigler; R S Turner

doi:10.1016/0165-0270(81)90047-9

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Methionine-enkephalin and morphine: amount ejected microiontophoretically.

D A Hosford·H J Haigler·R S Turner

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Abstract

The microiontophoretic transport numbers of Met-enkephalin and morphine were determined by ejecting the tritiated compounds from both 5-barrel and 7-barrel micro-pipettes into a small volume of 0.9% NaCl, using a series of ejection currents and various timed durations. The transport number of Met-enkephalin was 2-4 times less than that for morphine in 5- and 7-barrel pipettes. The transport numbers of both drugs in 5-barrel pipettes were significantly greater than those in 7-barrel pipettes. These results indicate the need for caution in comparing the data derived from different studies that use microiontophoresis. The transport numbers for morphine and Met-enkephalin were used to compare the effects of these agents on neuronal firing.

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Animals Biological Transport Endorphins Enkephalin, Methionine Enkephalins Evoked Potentials Iontophoresis Kinetics Microinjections Morphine Neurons Tritium Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

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D A Hosford, H J Haigler, R S Turner. 1981. Methionine-enkephalin and morphine: amount ejected microiontophoretically.. https://doi.org/10.1016/0165-0270(81)90047-9

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