Cerebral cortex responds rapidly to thyroid hormones.

J L Leonard; M M Kaplan; T J Visser; J E Silva; P R Larsen

doi:10.1126/science.7291997

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PubMed · 7291997

Cerebral cortex responds rapidly to thyroid hormones.

J L Leonard·M M Kaplan·T J Visser·J E Silva·P R Larsen

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Abstract

In rats subjected to thyroidectomy there was a two- to fourfold increase in cerebral cortex iodothyronine 5'-deiodinase activity within 24 hours. This increase was prevented by thyroxine replacement. The increased cortical 5'-deiodinase in chronically hypothyroid rats was normalized within 4 hours by a single intravenous injection of triiodothyronine. These results indicate that the adult central nervous system can give a very rapid biochemical response to thyroid hormone.

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Animals Cerebral Cortex Iodide Peroxidase Liver Male Peroxidases Rats Rats, Inbred Strains Thyroidectomy Thyroxine Time Factors Triiodothyronine Triiodothyronine, Reverse Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

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J L Leonard, M M Kaplan, T J Visser, J E Silva, P R Larsen. 1981-10-30. Cerebral cortex responds rapidly to thyroid hormones.. https://doi.org/10.1126/science.7291997

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