Conformational changes and drug action.

A S Burgen

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PubMed · 7297703

Conformational changes and drug action.

A S Burgen

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Abstract

Conformational changes induced or selected by drugs in receptors may be coupled to second sites on receptor molecules giving negative or positive cooperative binding. The structure-activity relationships may be changed depending on the predominant conformation. Some conformational changes can be identified by nuclear magnetic resonance spectroscopy. Conformational coupling between subunits is complex and provides a mechanism for modulation of receptor affinity.

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Animals Binding Sites Histidine Humans Kinetics Magnetic Resonance Spectroscopy NADP Protein Binding Protein Conformation Receptors, Drug Structure-Activity Relationship Tetrahydrofolate Dehydrogenase Journal Article

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A S Burgen. 1981. Conformational changes and drug action.. https://pubmed.ncbi.nlm.nih.gov/7297703/

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