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A stable parenteral solution of apomorphine.

W J Decker·D G Corby·H F Combs
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Abstract

A sterile, stable apomorphine preparation suitable for parenteral use was prepared by dissolving 0.3% w/v powdered apomorphine hydrochloride in 1% reduced l-ascorbic acid. The solution was then sterilized by filtration through a 0.22 -micrometer Millipore filter, the air in the vial was replaced by nitrogen, and the vials were sealed and stored at 5 degrees C in the dark. Under these conditions the apomorphine solutions remained water-clear and retained their potency for at least 1 year following preparation.

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AntioxidantsApomorphineAscorbic AcidInfusions, ParenteralSolutionsSterilizationTime FactorsJournal Article

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W J Decker, D G Corby, H F Combs. 1981. A stable parenteral solution of apomorphine.. https://doi.org/10.3109/15563658108990303

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