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Naltrexone and the tail flick reflex.

C Advokat
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Abstract

Rats who received a tail flick test following repeated injections of 5 mg/kg of morphine were significantly more tolerant than rats who were not tested after each injection. Administration of 0.5 mg/kg of naltrexone hydrochloride, prior to the morphine injections, prevented the development of tolerance, increased analgesic latencies and abolished the difference between tested and nontested animals.

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AnalgesicsAnimalsDrug InteractionsDrug ToleranceMaleMorphineNaloxoneNaltrexoneNociceptorsRatsRats, Inbred StrainsReflexJournal ArticleResearch Support, U.S. Gov't, P.H.S.

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C Advokat. 1981. Naltrexone and the tail flick reflex.. https://doi.org/10.1016/0091-3057(81)90003-4

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