Conditioned gustatory avoidance induced by three cholinergic agents.

K L Preston; C R Schuster

doi:10.1016/0091-3057(81)90030-7

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Conditioned gustatory avoidance induced by three cholinergic agents.

K L Preston·C R Schuster

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Abstract

Conditioned gustatory avoidance of sweetened condensed milk was induced in rats by drugs which differentially affect the cholinergic nervous system. After baseline water intake during a 15 minute daily session was established, sweetened condensed milk was presented in place of water, followed 15 minutes later by an IP injection of saline, physostigmine (0.5 mg/kg), atropine (25 mg/kg) or mecamylamine (25 mg/kg). Three presentations of milk were given, alternating daily with a water presentation. Atropine, a muscarinic blocker, and mecamylamine, a nicotinic blocker, both produced a strong avoidance. Physostigmine, an indirect agonist, produced a less pronounced avoidance at the dose employed. This study indicates that cholinergic agonists and antagonists are capable of inducing conditioned gustatory avoidance.

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Animals Atropine Avoidance Learning Male Mecamylamine Milk Parasympathomimetics Physostigmine Rats Rats, Inbred Strains Taste Journal Article Research Support, U.S. Gov't, P.H.S.

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K L Preston, C R Schuster. 1981. Conditioned gustatory avoidance induced by three cholinergic agents.. https://doi.org/10.1016/0091-3057(81)90030-7

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