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Prolactin and contact sensitivity.

E Nagy·I Berczi
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Abstract

Hypophysectomized (Hypo-X) rats did not develop contact dermatitis in response to dinitrochlorobenzene (DNCB). Syngeneic pituitary grafts placed under the kidney capsule or daily treatment with prolactin restored the DNCB-reactivity of Hypo-X animals. Combined treatment with other pituitary hormones was ineffective. Treatment of normal rats with a potent prolactin antagonist drug, bromocriptine, was as effective in inhibiting contact sensitivity as was hypophysectomy. These results indicate the contact sensitivity is a prolactin dependent reaction.

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AnimalsBromocriptineCattleDermatitis, ContactDinitrochlorobenzeneFemaleHumansHypophysectomyPituitary GlandProlactinRatsRats, Inbred F344Journal ArticleResearch Support, Non-U.S. Gov't

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E Nagy, I Berczi. 1981. Prolactin and contact sensitivity.. https://doi.org/10.1111/j.1398-9995.1981.tb01850.x

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