Enzyme studies and neonatal brain damage.

B Dalens; J L Viallard; E J Raynaud; B Dastugue

doi:10.1111/j.1651-2227.1981.tb05779.x

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Enzyme studies and neonatal brain damage.

B Dalens·J L Viallard·E J Raynaud·B Dastugue

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Abstract

The authors report a double-blind study of 57 full-term newborn infants prospectively subjected to clinical, electroencephalographical, blood and cerebrospinal fluid, and developmental examinations. Four enzymatic activities were measured in blood and CSF: aminotransferase (ASAT), creatine kinase (CK), lactate dehydrogenase (LD) and hydroxybutyrate dehydrogenase (HBD). Close relationships of enzymatic levels with psychomotor outcome are reported. In blood, ASAT and CL seemed to be the most important determinations, allowing threshold-values to be suggested. In CSF, LD and HBD were the determinations the most closely related to psychomotor events at age one. This method seems to be of theoretical as well as practical importance in evaluating neonatal brain injury.

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Apgar Score Brain Damage, Chronic Clinical Enzyme Tests Creatine Kinase Double-Blind Method Humans Hydroxybutyrate Dehydrogenase Infant, Newborn L-Lactate Dehydrogenase Prospective Studies Psychomotor Disorders Transaminases Clinical Trial Controlled Clinical Trial Journal Article

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B Dalens, J L Viallard, E J Raynaud, B Dastugue. 1981. Enzyme studies and neonatal brain damage.. https://doi.org/10.1111/j.1651-2227.1981.tb05779.x

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