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The topically irritant substance: essentials - bio-tests - predictions.

K Bucher·K E Bucher·D Walz
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Abstract

The paper describes a method for judging the irritative potentialities of substances; proposes a scoring system with which the 'ordinary' risks of many of the abundant marketed products for washing, cleaning etc. may be predicted without biological testing; discusses pharmacodynamic and pharmacokinetic aspects of topical irritancy and points to the problems of extrapolating from animal experiments to man.

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AnimalsDrug Evaluation, PreclinicalHumansHydrogen-Ion ConcentrationIrritantsMiceSolventsJournal ArticleResearch Support, Non-U.S. Gov't

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K Bucher, K E Bucher, D Walz. 1981. The topically irritant substance: essentials - bio-tests - predictions.. https://doi.org/10.1007/bf02004715

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