Composite randomization designs for clinical trials.

R Simon

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PubMed · 7337792

Composite randomization designs for clinical trials.

R Simon

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Abstract

This paper proposes a new design for the augmentation of a randomized clinical trial through the participation of private physicians who do not randomize individual patients. Each private physician is randomly assigned a study treatment which he or she uses consistently for all eligible patients. A statistically rigorous method of analysis is described, the efficiency of this design is evaluated, and its limitations discussed.

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R Simon. 1981. Composite randomization designs for clinical trials.. https://pubmed.ncbi.nlm.nih.gov/7337792/

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