Decrease in effects of muscimol on the dorsal root after repeated administration of diazepam in rats.

T Kaneko; H Ono; H Fukuda

doi:10.1248/bpb1978.4.947

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Decrease in effects of muscimol on the dorsal root after repeated administration of diazepam in rats.

T Kaneko·H Ono·H Fukuda

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Abstract

In in situ experiments on spinal rats transected at the C1 level and on non-spinal rats, muscimol (3 mg/kg, i.v.) depolarized the primary afferent fibers and diazepam (3 mg/kg, i.v.) potentiated this effect of muscimol. When diazepam was given for 14 days, the effect of muscimol was significantly reduced in non-spinal rats. These findings suggest that diazepam probably interacts with GABA-ergic mechanisms more closely in supraspinal regions of the rat.

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Animals Bicuculline Diazepam Male Membrane Potentials Muscimol Oxazoles Rats Rats, Inbred Strains Spinal Nerve Roots Time Factors gamma-Aminobutyric Acid Journal Article Research Support, Non-U.S. Gov't

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T Kaneko, H Ono, H Fukuda. 1981. Decrease in effects of muscimol on the dorsal root after repeated administration of diazepam in rats.. https://doi.org/10.1248/bpb1978.4.947

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