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PubMed · 7349575

Experimental corticosteroid myopathy.

P W Braunstein·U DeGirolami
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Abstract

The steroids triamcinolone, dexamethasone, beta-methasone, and cortisone were administered i.p. to adult rats for 14-63 days. The extensor digitorum longus (EDL, white muscle) and soleus (SOL, red muscle) muscles were examined histologically and histochemically. Triamcinolone was the most potent lesion-producing drug. Selective involvement of muscles, and of the fiber types within them was observed: Necrotic changes were seen only in the type 1 fibers of the SOL; atrophic fibers were observed in the type 2 fibers of both the SOL and the EDL.

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Adrenal Cortex HormonesAnimalsBetamethasoneCortisoneDexamethasoneMaleMusclesMuscular AtrophyNecrosisRatsRats, Inbred StrainsTriamcinoloneJournal Article

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P W Braunstein, U DeGirolami. 1981. Experimental corticosteroid myopathy.. https://doi.org/10.1007/bf00691314

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