Cerebellar tRNA methyltransferases: a developmental study.

J Dainat; O Z Sellinger

doi:10.1016/0006-8993(80)90125-0

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Cerebellar tRNA methyltransferases: a developmental study.

J Dainat·O Z Sellinger

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Abstract

Developmental patterns of homologous and heterologous tRNA methylation by cerebellar tRNA methyltransferases are described. The study revealed that: (a) homologous tRNA methylation results in the predominant formation of N2-methylguanine and 1-methyladenine; (b) tRNA methyltransferase of bulk-isolated Purkinje and granule cells methylate E. coli tRNAglu2 in vitro in a characteristic manner, and (c) the methylation of 8-day-old cerebellar, cortical and hepatic tRNA in vivo yields tRNAs containing different proportions of methylated bases. The findings suggest that the presumably cell-specific populations of cerebellar tRNA methyltransferases continue to alter their substrate recognition characteristics up to and beyond the first month of post-natal life.

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Aging Animals Cerebellum Cytosine Guanine Kinetics Male Methylation Purkinje Cells Rats tRNA Methyltransferases Journal Article Research Support, U.S. Gov't, P.H.S.

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J Dainat, O Z Sellinger. 1980-02-03. Cerebellar tRNA methyltransferases: a developmental study.. https://doi.org/10.1016/0006-8993(80)90125-0

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