Long-term interactions between endogenous and exogenous opiates.

Y Sarne; Y Gothilf; B A Weissman

doi:10.1016/0014-2999(80)90488-4

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Long-term interactions between endogenous and exogenous opiates.

Y Sarne·Y Gothilf·B A Weissman

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Abstract

The in vitro biological effect of various opiates was studied in the guinea pig ileum bioassay. Besides their direct, immediate effect, certain opiates induced sensitivity changes which persisted after their removal and the complete recovery of the preparation. These specific, asymmetrical interactions may represent long-term modulation of the opiate receptor. The in vivo pharmacological implication of opiate interaction is discussed.

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Animals Drug Interactions Endorphins Enkephalins Guinea Pigs In Vitro Techniques Morphine Muscle Contraction Muscle, Smooth Narcotics Time Factors Journal Article

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Y Sarne, Y Gothilf, B A Weissman. 1980-03-07. Long-term interactions between endogenous and exogenous opiates.. https://doi.org/10.1016/0014-2999(80)90488-4

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