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Adipocyte size distribution in fa/fa rats during development.

M L Kaplan·J R Trout·P Smith
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Abstract

Epididymal fat pad adipocyte frequency distributions of obese (fa/fa) and nonobese (non-fa/fa) Zucker rats were determined from 2 to 20 wk of age. The fa/fa rats consistently displayed a higher proportion of larger adipocytes than the non-fa/fa rats of all ages studied. Increased adipocyte size preceded an increase in the number of adipocytes during the early phases of obese development. Among the fa/fa rats, the frequency of small cells continued to increase, which resulted in a bimodal distribution by 20 wk of age. Discriminant analysis suggests that the differences in adipocyte size frequency distributions at 2 wk of age may be another useful means to identify fa/fa and non-fa/fa pups prior to expression of overt obesity. Increased fat storage may reflect the lower energy expended by the very young fa/fa rats.

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Adipose TissueAgingAnimalsDisease Models, AnimalEpididymisFemaleHomozygoteMaleObesityPhenotypePregnancyRatsJournal ArticleResearch Support, U.S. Gov't, P.H.S.

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M L Kaplan, J R Trout, P Smith. 1980. Adipocyte size distribution in fa/fa rats during development.. https://doi.org/10.1016/0026-0495(80)90006-2

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