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Oncogenic transformation and hyperthermia.

L Harisiadis·R C Miller·S Harisiadis·E J Hall
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Abstract

The potential of hyperthermia for producing oncogenic transformation in vitro was assessed using C3H/10T 1/2 mouse embryo cells. Temperatures in the range of 40 degrees to 45 degrees C caused no transformations, whether or not the heat treatment was associated with significant cell killing. In addition modest hyperthermia appreciably reduced the transformation frequencies associated with X-ray doses. The findings suggest an additional benefit in combining ionizing radiations with hyperthermia.

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AnimalsCell SurvivalCell Transformation, NeoplasticClone CellsDose-Response Relationship, RadiationHot TemperatureMiceMice, Inbred StrainsJournal ArticleResearch Support, U.S. Gov't, P.H.S.

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L Harisiadis, R C Miller, S Harisiadis, E J Hall. 1980. Oncogenic transformation and hyperthermia.. https://doi.org/10.1259/0007-1285-53-629-479

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