PubMed Health⌕ Search
Home/Archive/PubMed

PubMed · 7396624

Colonic telangiectasias in scleroderma.

J B Marshall·G F Moore·R H Settles
View original source ↗Export metadata ↓

Abstract

Gastrointestinal tract involvement in progressive systemic sclerosis (PSS) is common. A 46-year-old woman with PSS and calcinosis, Raynaud's phenomenon, esophageal hypomotility, sclerodactyly, and telangiectasias with evidence of widespread intestinal tract involvement is described in whom multiple colonic telangiectasias (angiodysplasias) were found on colonoscopy, a finding not previously reported to our knowledge. The telangiectasias represent a potential cause of gastrointestinal tract bleeding.

Explore related subjects

Colonic DiseasesFemaleHumansMiddle AgedScleroderma, SystemicTelangiectasisCase ReportsJournal Article

Keep this discovery

Explore connections, maps & timelines

BibTeXRIS

J B Marshall, G F Moore, R H Settles. 1980. Colonic telangiectasias in scleroderma.. https://pubmed.ncbi.nlm.nih.gov/7396624/

Cite the original work for its findings. Save a collection to share your selection of sources.

KEEP EXPLORING

Related citations

PubMed2012

Crohn's disease.

Crohn's disease is a relapsing systemic inflammatory disease, mainly affecting the gastrointestinal tract with extraintestinal manifestations and associated immune disorders. Genome wide association studies identified susceptibility loci that--triggered by environmental factors--result in a disturbed innate (ie, disturbed intestinal barrier, Paneth cell dysfunction, endoplasmic reticulum stress, defective unfolded protein response and autophagy, impaired recognition of microbes by pattern recognition receptors, such as nucleotide binding domain and Toll like receptors on dendritic cells and macrophages) and adaptive (ie, imbalance of effector and regulatory T cells and cytokines, migration and retention of leukocytes) immune response towards a diminished diversity of commensal microbiota. We discuss the epidemiology, immunobiology, amd natural history of Crohn's disease; describe new treatment goals and risk stratification of patients; and provide an evidence based rational approach to diagnosis (ie, work-up algorithm, new imaging methods [ie, enhanced endoscopy, ultrasound, MRI and CT] and biomarkers), management, evolving therapeutic targets (ie, integrins, chemokine receptors, cell-based and stem-cell-based therapies), prevention, and surveillance.

Colonic Diseases↗