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Platelet factor 4 regulates osteoclastic bone resorption in vitro.

J E Horton·J Harper·E Harper
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Abstract

Platelet factor 4, which inhibits collagenases derived from both human skin and granulocytic extracts, was found to block reversibly parathyroid hormone-stimulated 45Ca release from fetal rat bone in vitro. The inhibitory property was equally effective in both actively resorbing bones and in bones stimulated to initiate resorption.

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AnimalsBlood Coagulation FactorsBone ResorptionFetusOsteoclastsParathyroid HormonePlatelet Factor 4RatsJournal ArticleResearch Support, U.S. Gov't, P.H.S.

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J E Horton, J Harper, E Harper. 1980-07-03. Platelet factor 4 regulates osteoclastic bone resorption in vitro.. https://doi.org/10.1016/0304-4165(80)90295-0

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