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PubMed · 7398073

Serum ferritin: physiological and methodological studies.

G Birgegård
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Abstract

Some aspects of normal ferritin physiology have been investigated as well as methodological problems concerning test sample handling etc. No circadian rhythm was found in 11 subjects. The day-to-day variation showed a mean of 9% in 22 subjects, but with considerable individual variation. The ferritin content in erythrocytes was about 0.045 fg/cell, and in leucocytes about 10 fg/cell. Hemolysis of test samples up to a hemoglobin concentration of 3 g/l in the serum did not significantly change the ferritin concentration. This means that hemolysis of test samples is usually no problem in clinical practice. Serum samples could be stored at -20 degrees C for a year or freeze-thawed six times without change in ferritin concentration. Heparin- and sodium citrate plasma gve the same resuls as serum, but EDTA plasma gave 23% (mean) lower values. A moderate amount of alcohol, corresponding to 25 cl of whisky, gave no rise within 56 h in serum ferritin levels in four subjects.

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CentrifugationCircadian RhythmErythrocytesEthanolFerritinsHeparinHumansLeukocytesRadioimmunoassayTime FactorsJournal Article

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G Birgegård. 1980-05-09. Serum ferritin: physiological and methodological studies.. https://doi.org/10.1016/0009-8981(80)90146-1

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