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PubMed · 7408409

Interaction between diflunisal and warfarin.

M J Serlin·S Mossman·R G Sibeon·K F Tempero·A M Breckenridge
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Abstract

The effect of diflunisal on steady-state warfarin dynamics and kinetics was studied in five healthy men taking daily subtherapeutic doses of warfarin. Diflunisal 500 mg twice daily for 2 wk increased the percentage unbound warfarin from 1.02% to 1.24% and lowered total warfarin from 741 to 533 ng/ml, but did not alter the anticoagulant response (prothrombin complex activity, PCA). When diflunisal was discontinued but warfarin continued, there was a loss of anticoagulant effect and a difference in the rates at which percentage unbound warfarin and total warfarin concentration returned to prediflunisal levels. There was a correlation between plasma diflunisal and percentage unbound warfarin. Diflunisal reduced both the maximum plasma protein-binding capacity for warfarin and the apparent association constant.

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AbsorptionAdultBlood ProteinsDiflunisalDose-Response Relationship, DrugDrug InteractionsHumansMaleProtein BindingProthrombinSalicylatesWarfarinJournal ArticleResearch Support, Non-U.S. Gov't

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M J Serlin, S Mossman, R G Sibeon, K F Tempero, A M Breckenridge. 1980. Interaction between diflunisal and warfarin.. https://doi.org/10.1038/clpt.1980.193

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