[Aerosol method of using interferon inducers].

N N Nosik; V I Balashov; L A Bukata; A N Fomina; F I Ershov

PubMed · 7423975

[Aerosol method of using interferon inducers].

N N Nosik·V I Balashov·L A Bukata·A N Fomina·F I Ershov

Abstract

A method for aerosol use of interferon inducer in laboratory animals employing an ultrasonic aerosol generator is described. Formules and a table of calculations of an inhalation dose of interferon inducer in solution when atomized in a chamber, as well as in the use of individual masks for monkeys are presented. The aerosol administration of interferon inducer (replicative from RNA of phage f2) was found to be effective in inducing interferon production in mice and monkeys. Prophylactic administration of the inducer 4 and 24 hours before inoculation protected from 50% to 75% of mice against a fatal influenza infection.

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Aerosols Animals Bacteriophages Chlorocebus aethiops Dose-Response Relationship, Immunologic Interferon Inducers Mice Orthomyxoviridae Infections RNA, Double-Stranded RNA, Viral Time Factors Journal Article

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N N Nosik, V I Balashov, L A Bukata, A N Fomina, F I Ershov. [Aerosol method of using interferon inducers].. https://pubmed.ncbi.nlm.nih.gov/7423975/

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