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Neonatal thyroid function and anaesthesia.

S Halevy·M Liu-Barnett·P L Ross
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Abstract

Thyroid function in the neonate and its response to hexobarbitone anaesthesia were studied in newborn Wistar rats between 24 h and 42 days old. 14C-labelled mixed with unlabelled hexobarbitone was injected i.p. in anaesthetic concentrations. Serum T3, reverse T3 (rT3) and T4 and serum and whole brain hexobarbitone concentrations were measured on wakening. A decrease in serum T3 and rT3 and an increase in T4 concentrations were observed after hexobarbitone at 21 and 30 days. This appears to be a critical period in the neonatal rat. A significant negative correlation was found between the changes in serum thyroid hormone concentrations and whole-brain concentrations of hexobarbitone in 30-day-old male rats. It is suggested that similar effects may occur in the human fetus or neonate subjected to anaesthesia.

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Anesthesia, GeneralAnimalsAnimals, NewbornBrainFemaleHexobarbitalMaleRatsThyroid GlandThyroxineTriiodothyronineTriiodothyronine, ReverseJournal ArticleResearch Support, Non-U.S. Gov't

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S Halevy, M Liu-Barnett, P L Ross. 1980. Neonatal thyroid function and anaesthesia.. https://doi.org/10.1093/bja%2F52.10.975

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