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PubMed · 7438685

Buprenorphine kinetics.

R E Bullingham·H J McQuay·A Moore·M R Bennett
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Abstract

Buprenorphine kinetics was determined in surgical patients using radioimmunoassay. Buprenorphine was measured in the plasma of 24 patients who had received 0.3 mg buprenorphine intraoperatively. After 3 hr 10 of these patients then received a further 0.3 mg buprenorphine intravenously for postoperative pain relief, and 11 patients were given 0.3 mg intramuscularly; again, plasma levels were measured for 3 hr. The data fitted closely to a triexponential decay curve. There was a very fast initial phase, with a half-life (t1/2) of 2 min. The terminal t1/2 was slow, approximately 3 hr. Comparison of the kinetics of the same patient, awake and anesthetized, showed that the clearance was significantly lower in the anesthetized state. A notable feature of the drug given intramuscularly is rapid systemic availability, so that peaks are obtained in 2 to 5 min, and in 10 min the resulting levels are the same as for the intravenous and intramuscular routes.

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AnesthesiaBuprenorphineFemaleHumansInjections, IntramuscularKineticsMaleMorphinansJournal Article

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BibTeXRIS

R E Bullingham, H J McQuay, A Moore, M R Bennett. 1980. Buprenorphine kinetics.. https://doi.org/10.1038/clpt.1980.219

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