Pallidosubthalamic projection in the cat. Electron microscopic study.

Abstract

The degenerative changes within the cat's subthalamic nucleus (Sth) following lesions of the external pallidum were studied by electron microscopy. Four to five days following pallidal lesions a great number of terminals undergoing degenerative changes were encountered in the ipsilateral Sth. The contralateral Sth was free of degeneration. The degenerating terminals show predominantly the light degenerative type, less frequently the dark degenerative pattern, and occasionally exhibit signs of filamentous hyperplasia. The degenerated boutons usually insert on perikarya of the large Sth neurons, on proximal dendrites, and more rarely contact dendritic spines. They were observed neither to perform synaptic contacts with the perikarya of the small Sth neurons nor with other vesicle-containing profiles. On the basis of the ultrastructural aspect of the degenerating terminals, they were identified as F1 terminals, discriminated in a previous study (Romansky et al., 1978). The normal appearance, the synaptic relationships, and the degenerative features of the F1 terminials in the Sth closely resemble the entopeduncular terminals in the thalamus described by Rinvik and Grofová (1974a), and Grofová and Rinvik (1974). The possible contribution of the interrupted passing fibers to the observed degeneration is discussed. The present findings corroborate the relevant morphological, physiological, neurochemical, and neuropharmacological data in the literature.