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PubMed · 7462214

Manganese effects on gluconeogenesis.

R Rognstad
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Abstract

Manganese (Mn2+) does not significantly increase gluconeogenesis from lactate (10 mM) plus pyruvate (1 mM) in hepatocytes from fasted rats. In hepatocytes not treated with Mn2+, glucagon (1 microM) and epinephrine (10 microM) at these optimal concentrations both stimulate gluconeogenesis from lactate/pyruvate (10:1), but the hormonal effects are not additive. In the presence of Mn2+ the hormonal effects are slightly larger, and the effects of glucagon (1 microM) and epinephrine (10 microM) become nearly completely additive. Mn2+ increases the specific activity of glucose formed from lactate plus NaH14CO3 by nearly 20%. The increase may be attributed to an increased exchange reaction of either pyruvate carboxylase or phosphoenolypyruvate carboxykinase, suggesting that one of these may be markedly stimulated by Mn2+, the increased exchange reaction possibly signifying an approach toward "near equilibrium" status.

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AnimalsCarbon RadioisotopesEpinephrineGlucagonGluconeogenesisIsotope LabelingKineticsLactatesLiverMaleManganeseRatsJournal ArticleResearch Support, U.S. Gov't, P.H.S.

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R Rognstad. 1981-02-25. Manganese effects on gluconeogenesis.. https://pubmed.ncbi.nlm.nih.gov/7462214/

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