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Ketamine: convulsant or anti-convulsant?

M S Myslobodsky·V Golovchinsky·M Mintz
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Abstract

Ketamine hydrochloride in doses producing narcotic-cataleptic effects (50--100 mg/kg, IP) reduced the intensity of picrotoxin convulsions and eliminated seizures caused by metrazol administration. Subcataleptic doses (5--20 mg/kg) increased the duration of mitigated convulsive symptoms (abortive grand mal fits, jerks) especially those evoked by picrotoxin. Narcotic-cateleptic doses of ketamine considerably increased the duration of the period of single and multiple jerks produced by picrotoxin administration. Both convulsants transformed 1--2 Hz "ketamine complexes" into 2--4 Hz Wave spike discharges which appeared in a quasi-periodic fashion alternating with periods of relatively suppressed electrocortical activity. Electroencephalographic grand mal patterns were typically dissociated from behavioral manifestations under 50--100 mg/kg of ketamine, followed by a short period of postictal depression and a rapid recovery of preseizure electrographic patterns. Findings suggest that mechanisms involved in seizure alleviation may be responsible for sustaining mitigated convulsive phenomena. Neuro-chemical processes underlying antiepileptic ketamine potency remain unknown.

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AnimalsAnticonvulsantsConvulsantsDrug InteractionsElectroencephalographyKetamineMalePentylenetetrazolePicrotoxinRatsJournal ArticleResearch Support, Non-U.S. Gov't

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M S Myslobodsky, V Golovchinsky, M Mintz. 1981. Ketamine: convulsant or anti-convulsant?. https://doi.org/10.1016/0091-3057(81)90099-x

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