Towards a general function describing T cell proliferation.

R J De Boer; A S Perelson

doi:10.1006/jtbi.1995.0165

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Towards a general function describing T cell proliferation.

R J De Boer·A S Perelson

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Abstract

A new function is proposed for describing the rate of T cell proliferation in response to peptides on antigen-presenting cells. The model improves an earlier model of ours by allowing for a true maximum proliferation rate of the T cells. This is achieved by a simple change of variables that markedly relaxes the conditions for a conventional quasi-steady-state assumption. The new model has the same "ecological" properties as the previous one. Thus the natural competition in the model allows for regulation of T cell population size in the presence of continuous stimulation by antigen. An important feature is the competitive exclusion of T cell clones recognizing the same peptide with different affinities allowing for "affinity selection". Models for the population dynamics of experienced, naïve and activated T cells are also developed. These T cell subpopulations compete with one another for antigen. In models with lymphokine production a "proliferation threshold" is obtained that allows for tolerance.

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Animals Antigen-Presenting Cells Cell Division Immunity, Cellular Lymphocyte Activation Mathematics Models, Immunological T-Lymphocyte Subsets T-Lymphocytes Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

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R J De Boer, A S Perelson. 1995-08-21. Towards a general function describing T cell proliferation.. https://doi.org/10.1006/jtbi.1995.0165

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