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PubMed · 7482705

GPI-anchor biosynthesis.

J Takeda·T Kinoshita
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Abstract

Many eukaryotic proteins bind to membranes using a glycosylphosphatidylinositol (GPI) anchor. GPI anchors are essential in yeasts and probably also in protozoa. Although mammalian cells can survive without GPI anchors, their deficiency in haemopoietic cells cause a haemolytic disease, paroxysmal nocturnal haemoglobinuria (PNH). Here, we discuss recent progress in our understanding of GPI-anchor biosynthesis that could lead to a better understanding of PNH and chemotherapeutic agents to treat protozoal and fungal infections.

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AnimalsCarbohydrate SequenceGlycosylphosphatidylinositolsHumansMolecular Sequence DataJournal ArticleResearch Support, Non-U.S. Gov'tReview

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J Takeda, T Kinoshita. 1995. GPI-anchor biosynthesis.. https://doi.org/10.1016/s0968-0004(00)89078-7

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