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PubMed · 7483357

[Endogenous digitalis-like substance. I. Basic characteristics].

E Martinka
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Abstract

Endogenous digitalis-like substances (EDLS) present endogenous products which structurally belong to cardiac glycosides (CG). According contemporary views these substances potentially present a newly discovered hormonal group produced by adrenal cortex. EDLS, similarly exogenous CG, bind to specific CG- receptor of Na(+)-K(+)-ATPase and inhibit activity of this enzyme. At the cellular level, EDLS lead to increase in intracellular calcium storing and such may play an important role in modulation of calcium-dependent processes and their response to characteristic stimuli (e.g. contractility of vascular smooth muscle cells, hormonal secretion etc.). First part is a review of present views to character and cellular effects of EDLS.

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E Martinka. 1995. [Endogenous digitalis-like substance. I. Basic characteristics].. https://pubmed.ncbi.nlm.nih.gov/7483357/

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