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A brain-specific G protein gamma subunit.

S Kalyanaraman·V Kalyanaraman·N Gautam
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Abstract

Two different cDNAs for G protein gamma subunits have been isolated from mouse brain. One encodes a novel gamma subunit, gamma 4, the expression of which is detected only in brain. A fragment of this cDNA had been isolated previously. The other cDNA encodes gamma 3, a subunit type previously isolated from bovine brain. The primary structure of the gamma 3 subunit is conserved completely across species indicating that the diversity in the structure of the gamma subunits is of functional consequence. Moreover, gamma 2, gamma 3 and gamma 4, which are predominantly expressed in brain, are more homologous to each other than other gamma subunits, indicating that the G protein gamma subunits belong to distinct subfamilies similar to the alpha subunits.

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Amino Acid SequenceAnimalsBase SequenceBrainCattleCloning, MolecularDNA PrimersDNA, ComplementaryGTP-Binding ProteinsGene LibraryMacromolecular SubstancesMiceMolecular Sequence DataOrgan SpecificityPolymerase Chain ReactionSequence Homology, Amino AcidSpecies SpecificityComparative StudyJournal ArticleResearch Support, Non-U.S. Gov'tResearch Support, U.S. Gov't, P.H.S.

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S Kalyanaraman, V Kalyanaraman, N Gautam. 1995-11-02. A brain-specific G protein gamma subunit.. https://doi.org/10.1006/bbrc.1995.2600

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