Age-related decrease of serotonergic fibres and S-100 beta immunoreactivity in the rat dentate gyrus.

A Nishimura; S Ueda; Y Takeuchi; T Sawada; M Kawata

doi:10.1097/00001756-199507100-00021

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Age-related decrease of serotonergic fibres and S-100 beta immunoreactivity in the rat dentate gyrus.

A Nishimura·S Ueda·Y Takeuchi·T Sawada·M Kawata

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Abstract

The age-related changes of serotonergic fibres and S-100 beta-positive astrocytes in the rat dentate gyrus were examined using immunohistochemistry. A significant reduction in the number of the serotonergic fibres and S-100 beta-positive astrocytes was observed throughout the dentate gyrus of the aged rat. A positive correlation was noted between the decrease of serotonergic fibres and S-100 beta-positive astrocytes in the aged rat dentate gyrus. These findings support the hypothesis that the age-related degeneration of serotonergic fibres in the dentate gyrus is caused by the decrease in serotonergic neurotrophic factor S-100 beta in the astrocytes.

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Aging Animals Astrocytes Dentate Gyrus Glial Fibrillary Acidic Protein Immunohistochemistry Nerve Degeneration Nerve Fibers Rats Rats, Wistar S100 Proteins Serotonin Journal Article

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A Nishimura, S Ueda, Y Takeuchi, T Sawada, M Kawata. 1995-07-10. Age-related decrease of serotonergic fibres and S-100 beta immunoreactivity in the rat dentate gyrus.. https://doi.org/10.1097/00001756-199507100-00021

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