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Efficient immune responses in mice lacking N-region diversity.

S Gilfillan·M Bachmann·S Trembleau·L Adorini·U Kalinke·R Zinkernagel·C Benoist·D Mathis
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Abstract

Mice with a null mutation in the terminal deoxynucleotidyl transferase (TdT) gene harbor immunoglobulin and T cell receptor repertoires essentially devoid of N-region diversity. Consequently, the CDR3 loops important for antigen recognition are shorter and considerably less diverse than those of wild-type controls. We find surprisingly normal immune responses in TdT0 mice, as regards both efficiency and specificity. This provokes a reconsideration of the assumption that N-region diversity is required for an effective T and B cell repertoire.

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Amino Acid SequenceAnimalsBase SequenceDNA NucleotidylexotransferaseEpitopesImmunoglobulinsLymphocytic choriomeningitis virusMiceMice, Mutant StrainsMolecular Sequence DataNeutralization TestsPolymorphism, GeneticReceptors, Antigen, T-CellVesicular stomatitis Indiana virusJournal ArticleResearch Support, Non-U.S. Gov't

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S Gilfillan, M Bachmann, S Trembleau, L Adorini, U Kalinke, R Zinkernagel, C Benoist, D Mathis. 1995. Efficient immune responses in mice lacking N-region diversity.. https://doi.org/10.1002/eji.1830251119

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