Practical aspects of hormone replacement therapy.

I H Thorneycroft

doi:10.1016/s0033-0620(95)80015-8

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Practical aspects of hormone replacement therapy.

I H Thorneycroft

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Abstract

Menopause is an endocrinopathy characterized by hypoestrogenism. Estrogen can be replaced easily. Available preparations can be taken by mouth, intramuscularly, transdermally, or transvaginally. Unopposed estrogens increase the risk of endometrial cancer, which can be overcome by the concomitant administration of a progestin agent. The progestin can be administered cyclically either every month, resulting in a monthly menses, or every 3 months, resulting in menses every 3 months. The progestin can also be administered every day, which achieves amenorrhea in over half of the patients; the remainder have breakthrough bleeding. Abnormal bleeding can be assessed by either endometrial biopsy or transvaginal ultrasound.

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Clinical Trials as Topic Contraindications Endometrial Hyperplasia Endometrial Neoplasms Endometrium Estrogen Replacement Therapy Estrogens Female Humans Osteoporosis, Postmenopausal Postmenopause Progestins Ultrasonography Journal Article Review

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I H Thorneycroft. Practical aspects of hormone replacement therapy.. https://doi.org/10.1016/s0033-0620(95)80015-8

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