Quality control in the secretory pathway.

C Hammond; A Helenius

doi:10.1016/0955-0674(95)80009-3

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Quality control in the secretory pathway.

C Hammond·A Helenius

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Abstract

Whereas newly synthesized proteins that have acquired a properly folded and assembled structure are transported from the endoplasmic reticulum to their final destinations, incompletely folded and assembled proteins are, as a rule, retained and eventually degraded. The molecular mechanisms of this unique molecular sorting phenomenon, called 'quality control', have been illuminated by recent studies.

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Animals Biological Transport Endoplasmic Reticulum Glycosylation Humans Membrane Proteins Molecular Chaperones Protein Folding Proteins Quality Control Journal Article Review

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C Hammond, A Helenius. 1995. Quality control in the secretory pathway.. https://doi.org/10.1016/0955-0674(95)80009-3

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