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Decrease of neurotrophin-3 mRNA in adult rat hippocampus after pilocarpine seizures.

R Schmidt-Kastner·L Olson
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Abstract

Neurotrophins such as NT-3 are subject to complex regulation during epileptic seizures. Pilocarpine at a dose of 250 mg/kg induced either limbic seizures (LS) or limbic motor status epilepticus (LMSE) in adult rats. In situ hybridization signals for NT-3 mRNA declined moderately after LS and were nearly lost in LMSE at 3-4 h. Loss of NT-3 mRNA expression does not correlate with cell death and may reflect a functional down-regulation in certain hippocampal neurons.

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AnimalsDisease Models, AnimalEpilepsyHippocampusIn Situ HybridizationMaleNerve Growth FactorsNeurotrophin 3PilocarpineRNA, MessengerRatsRats, Sprague-DawleySeizuresJournal ArticleResearch Support, Non-U.S. Gov'tResearch Support, U.S. Gov't, P.H.S.

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R Schmidt-Kastner, L Olson. 1995. Decrease of neurotrophin-3 mRNA in adult rat hippocampus after pilocarpine seizures.. https://doi.org/10.1006/exnr.1995.1096

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