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PubMed · 7502070

Equality for X chromosomes.

R L Kelley·M I Kuroda
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Abstract

In many species, females possess two X chromosomes and males have one X chromosome. This difference is critical for the initial determination of sex. However, the X encodes many functions required equally in males and females; thus, X chromosome expression must be adjusted to compensate for the difference in dosage between the sexes. Distinct dosage compensation mechanisms have evolved in different species. A common theme in the Drosophila melanogaster and Caenorhabditis elegans systems is that a subtle alteration of chromatin structure may impose this modest, but vital adjustment of the X chromosome transcription level.

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AnimalsCaenorhabditis elegansDosage Compensation, GeneticDrosophila ProteinsDrosophila melanogasterFemaleGenes, HelminthGenes, InsectMaleNuclear ProteinsRNA-Binding ProteinsSex CharacteristicsTranscription FactorsX ChromosomeJournal ArticleResearch Support, Non-U.S. Gov'tResearch Support, U.S. Gov't, P.H.S.Review

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R L Kelley, M I Kuroda. 1995-12-08. Equality for X chromosomes.. https://doi.org/10.1126/science.270.5242.1607

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