Methotrexate-induced leukoencephalopathy. A case report.

I Ilhan; A Cila; M Büyükpamukçu; C Akyüz; T Kutluk; S Berberoğlu

PubMed · 7502368

Methotrexate-induced leukoencephalopathy. A case report.

I Ilhan·A Cila·M Büyükpamukçu·C Akyüz·T Kutluk·S Berberoğlu

Abstract

A six-year-old girl with non-Hodgkin's lymphoma who was treated with both intravenous (IV) and intrathecal (IT) methotrexate and developed brain damage secondary to the cytostatic drug is described. This patient displayed hypertension, hypothermia/hyperthermia, lethargy, deterioration and coma as clinical findings, and bilateral, focal white matter hyperintensities in the occipital lobes were seen in her magnetic resonance imaging (MRI). Treatment-related leukoencephalopathy is one such adverse effect of IT methotrexate administration on the central nervous system and usually appears in a generalized form.

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Antimetabolites, Antineoplastic Brain Diseases Child Diagnosis, Differential Female Humans Lymphoma, Non-Hodgkin Magnetic Resonance Imaging Methotrexate Tomography, X-Ray Computed Case Reports Journal Article

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I Ilhan, A Cila, M Büyükpamukçu, C Akyüz, T Kutluk, S Berberoğlu. Methotrexate-induced leukoencephalopathy. A case report.. https://pubmed.ncbi.nlm.nih.gov/7502368/

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