Introduction to EDRF research.

R F Furchgott

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PubMed · 7504760

Introduction to EDRF research.

R F Furchgott

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Abstract

In response to acetylcholine, endothelial cells were shown to release a nonprostanoid factor, called endothelium-derived relaxing factor (EDRF), which caused relaxation of vascular smooth muscle. Since this discovery in 1980, many additional agents have been shown to stimulate release of EDRF from endothelium. Biological and chemical evidence has supported the proposal that EDRF is nitric oxide (NO), a potent vasodilator. Research on the synthesis, inhibition, and physiological roles of EDRF/NO has led to studies of this factor in vascular regulation and in various disease states, including hypertension, atherosclerosis, and diabetes.

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Animals Humans Muscle Relaxation Muscle, Smooth, Vascular Nitric Acid Nitric Oxide Research Journal Article Research Support, U.S. Gov't, P.H.S.Review

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R F Furchgott. 1993. Introduction to EDRF research.. https://pubmed.ncbi.nlm.nih.gov/7504760/

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