Methods to study peptides associated with MHC class I molecules.

S Joyce; S G Nathenson

doi:10.1016/0952-7915(94)90029-9

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Methods to study peptides associated with MHC class I molecules.

S Joyce·S G Nathenson

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Abstract

It is now an accepted fact that peptides of self or non-self origin form an essential component of the MHC class I structure. The peptide component of the heterotrimer contains the essential determinants recognized by the T-cell receptors of cytotoxic T lymphocytes, be it an antigen-specific, alloimmune or autoimmune response. Because of the importance of the recognition process, several methods have been developed to characterize naturally processed peptides presented by the class I molecules.

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Animals Epitopes Histocompatibility Antigens Class I Humans Immunologic Techniques Mass Spectrometry Peptides Radiochemistry Sequence Analysis T-Lymphocytes, Cytotoxic Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.Review

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S Joyce, S G Nathenson. 1994. Methods to study peptides associated with MHC class I molecules.. https://doi.org/10.1016/0952-7915(94)90029-9

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