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PubMed · 7516038

Cytotoxic T-cell memory without antigen.

L L Lau·B D Jamieson·T Somasundaram·R Ahmed
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Abstract

Memory is a hallmark of the immune system and ever since its recognition there has been considerable interest in understanding how immunity is maintained. The current model is that long-term memory is dependent on persistent antigenic stimulation. We report here results that challenge this view and provide evidence that antigen is not essential for the maintenance of CD8+ T-cell memory. We show that memory CD8+ cytotoxic T lymphocytes persist indefinitely in the absence of priming antigen, retain the memory phenotype (CD44hi), and provide protection against virus challenge. These findings suggest a re-evaluation of our current thinking on mechanisms involved in maintaining immunity and have implications towards designing effective vaccination strategies.

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AnimalsAntigens, ViralCD8 AntigensCarrier ProteinsCell LineCell SurvivalHyaluronan ReceptorsImmunologic MemoryImmunotherapy, AdoptiveLymphocytic ChoriomeningitisLymphocytic choriomeningitis virusMiceMice, Inbred BALB CMice, Inbred C57BLMice, SCIDModels, BiologicalReceptors, Cell SurfaceReceptors, Lymphocyte HomingT-Lymphocytes, CytotoxicJournal ArticleResearch Support, U.S. Gov't, P.H.S.

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L L Lau, B D Jamieson, T Somasundaram, R Ahmed. 1994-06-23. Cytotoxic T-cell memory without antigen.. https://doi.org/10.1038/369648a0

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