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PubMed · 7522009

T cells as antigen-presenting cells.

W J Pichler·T Wyss-Coray
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Abstract

Human T cells express major histocompatibility complex (MHC) class II antigens and adhesion molecules characteristic of antigen-presenting cells (APCs), and recent in vitro and in vivo evidence supports an antigen-presenting function for T cells. In this guise, T cells provide downregulatory signals for the immune response by inducing anergy in T cells that have already been activated and cytotoxicity in resting T cells. Here, Werner Pichler and Tony Wyss-Coray suggest that this may represent an important negative mechanism for T-cell homeostasis.

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Antigen PresentationAntigen-Presenting CellsAntigens, CDB7-1 AntigenB7-2 AntigenCell Adhesion MoleculesHumansLymphocyte ActivationMembrane GlycoproteinsT-LymphocytesJournal ArticleResearch Support, Non-U.S. Gov'tReview

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W J Pichler, T Wyss-Coray. 1994. T cells as antigen-presenting cells.. https://doi.org/10.1016/0167-5699(94)90078-7

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