pH and temperature modulate norepinephrine-dependent changes in endothelial permeability.

M P Griffin; J R Moorman

doi:10.1152/jappl.1994.76.6.2760

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pH and temperature modulate norepinephrine-dependent changes in endothelial permeability.

M P Griffin·J R Moorman

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Abstract

To evaluate the role of pH and temperature in norepinephrine (NE)-mediated decreases in endothelial permeability, we studied bovine pulmonary arterial endothelial monolayers at pH values of 4-9 and at temperatures of 35-39 degrees C. Only extremes of pH-modulated endothelial permeability and temperature had no effect. Although both NE and 3-isobutyl-1-methylxanthine decreased endothelial permeability, their effects were diminished by low pH and high temperature. Fever and acidosis may contribute to the edema seen in septic shock by a novel mechanism: attenuation of the barrier-improving function of NE.

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1-Methyl-3-isobutylxanthine Albumins Animals Cattle Cells, Cultured Endothelium, Vascular Hydrogen-Ion Concentration Norepinephrine Permeability Pulmonary Artery Temperature Journal Article Research Support, Non-U.S. Gov't

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M P Griffin, J R Moorman. 1994. pH and temperature modulate norepinephrine-dependent changes in endothelial permeability.. https://doi.org/10.1152/jappl.1994.76.6.2760

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