Structural elements required for receptor recognition of human interferon-gamma.

D L Lundell; S K Narula

doi:10.1016/0163-7258(94)90031-0

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Structural elements required for receptor recognition of human interferon-gamma.

D L Lundell·S K Narula

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Abstract

Interferon (IFN)-gamma is a central factor in numerous immune responses. Recently the three-dimensional structure of human and rabbit IFN-gamma has been elucidated. This review attempts to bring together the structure and function information into a working model of IFN-gamma: receptor interaction. Based on mutagenesis studies, and corroborated by work with peptides, antibodies and proteolytic digestion, three regions have been found to be important for receptor binding: a long loop connecting the A and B helices, His111 in the F helix and a conserved section of the flexible carboxyl terminus. These three regions may form one continuous binding domain.

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Amino Acid Sequence Animals Antibodies Binding Sites Epitopes Humans Interferon-gamma Molecular Sequence Data Mutagenesis Peptides Protein Conformation Receptors, Interferon Structure-Activity Relationship Comparative Study Journal Article Review

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D L Lundell, S K Narula. 1994. Structural elements required for receptor recognition of human interferon-gamma.. https://doi.org/10.1016/0163-7258(94)90031-0

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