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PubMed · 7532057

Interleukin-11.

S Kobayashi·M Teramura·K Oshimi·H Mizoguchi
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Abstract

Interleukin-11 (IL-11), a stromal cell-derived cytokine, has been known to act widely in hematopoietic and non-hematopoietic systems. IL-11 supports the growth of certain types of plasmacytoma and hybridoma cells, acts with interleukin-3 (IL-3) in shortening the Go period of early progenitors. IL-11 supports megakaryocyte colony formation and maturation, and acts as an autocrine growth factor in megakaryoblastic cell lines. In addition, IL-11 stimulates erythrocytopoiesis, enhances antigen-specific antibody responses, induces the synthesis of acute phase proteins, inhibits lipoprotein lipase activity and adipocyte differentiation, and promotes neuronal development. Administration of rhIL-11 to mice resulted in an increase of neutrophils and platelets. The human IL-11 gene is localized at 19q13.3-13.4, and codes 199 amino acids and 23 kDa with no N glycosylation. Its receptor and signal transduction share partially those of interleukin-6 (IL-6). Further analysis of its role in normal and pathological state is necessary to determine the exact function and its application for clinical uses.

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Acute-Phase ProteinsAdipose TissueAnimalsChromosomes, Human, Pair 19Erythroid Precursor CellsGenesHematopoietic Stem CellsHumansInterleukin-11Interleukin-11 Receptor alpha SubunitLymphocytesMegakaryocytesMiceNeuronsReceptors, InterleukinReceptors, Interleukin-11Signal TransductionJournal ArticleReview

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S Kobayashi, M Teramura, K Oshimi, H Mizoguchi. 1994. Interleukin-11.. https://doi.org/10.3109/10428199409051676

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