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Intermediate filaments in disease.

W H McLean·E B Lane
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Abstract

Intermediate filaments are major structural proteins encoded by a large multigene family. Their tissue-specific expression makes them important in studies of development, differentiation and pathology. Most intermediate filaments are keratins; recent discoveries of keratin mutations in a range of genetic skin disorders have clarified their role as providing essential structural support for cells in different physical settings.

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DNAEpidermolysis BullosaGenetic CodeGenetic LinkageHumansIntermediate FilamentsKeratinsMutationProtein Structure, TertiaryJournal ArticleReview

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W H McLean, E B Lane. 1995. Intermediate filaments in disease.. https://doi.org/10.1016/0955-0674(95)80053-0

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