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PubMed · 7546192

Th1 and Th2 subsets: paradigms lost?

A Kelso
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Abstract

The T helper 1 (Th1)/Th2 model has provided a valuable framework to investigate and explain many immune reactions and now pervades current thinking on the regulatory role of T cells. However, individual T cells and clones display remarkable diversity in their cytokine profiles, collectively forming a continuous spectrum in which Th1 and Th2 cells may be only two of the possible extreme phenotypes. For these reasons, Anne Kelso argues that cytokine-producing T cells cannot be classified into discrete subsets.

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AnimalsClone CellsCytokinesGene Expression RegulationImmunizationImmunophenotypingMiceMice, Inbred BALB CMice, Inbred C57BLMice, Inbred DBAModels, ImmunologicalT-Lymphocyte SubsetsTh1 CellsTh2 CellsJournal ArticleResearch Support, Non-U.S. Gov'tReview

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BibTeXRIS

A Kelso. 1995. Th1 and Th2 subsets: paradigms lost?. https://doi.org/10.1016/0167-5699(95)80004-2

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