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PubMed · 7546401

T helper cell differentiation in immune response.

S L Reiner·R A Seder
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Abstract

Significant progress has been made in understanding the maturation of antigen-specific CD4+ T helper cell responses. Recent progress centers on the network of cytokines, accessory molecules, and cell types that shapes the differentiation of distinct T helper cell subsets. Use of transgenic and knockout mice and well characterized in vivo models have helped clarify the interdependence or independence of many of these complex factors.

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AnimalsCell DifferentiationCytokinesGene ExpressionInterferon-gammaInterleukin-2Lymphocyte ActivationMiceMice, Inbred BALB CMice, KnockoutMice, TransgenicModels, ImmunologicalPolymorphism, GeneticSignal TransductionT-Lymphocytes, Helper-InducerTh1 CellsTh2 CellsJournal ArticleResearch Support, Non-U.S. Gov'tResearch Support, U.S. Gov't, P.H.S.Review

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S L Reiner, R A Seder. 1995. T helper cell differentiation in immune response.. https://doi.org/10.1016/0952-7915(95)80111-1

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