Molecular mechanisms underlying functional T-cell unresponsiveness.

D L Mueller; M K Jenkins

doi:10.1016/0952-7915(95)80113-8

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Molecular mechanisms underlying functional T-cell unresponsiveness.

D L Mueller·M K Jenkins

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Abstract

Evidence from tissue culture experiments and in vivo studies indicates that certain forms of antigen presentation render T cells unresponsive to subsequent antigenic stimulation. Great progress has been made recently in understanding the induction, maintenance, and in vivo relevance of this unresponsive state, called clonal anergy.

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Animals Cells, Cultured Humans Immune Tolerance Immunocompetence Interleukin-2 Mice Mice, Transgenic Models, Immunological Signal Transduction T-Lymphocytes Journal Article Review

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D L Mueller, M K Jenkins. 1995. Molecular mechanisms underlying functional T-cell unresponsiveness.. https://doi.org/10.1016/0952-7915(95)80113-8

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