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Structural polymorphism and function of HLA-B27.

J A López de Castro
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Abstract

Over the past year, new subtypes have been described and significant advances have been made in understanding peptide binding to HLA-B27. These developments help in interpreting how antigen presentation is modulated by HLA-B27 polymorphism, in determining the similarities and differences in T cell antigenicity among subtypes, and in finding the basis of HLA-B27 evolution. New insights into the pathogenetic link between enteric bacteria and HLA-B27 come from demonstration of a direct relationship between gut flora and joint inflammation in transgenic rats and from involvement of HLA-B27 in modulating bacterial invasion of mammalian cells. The association between HLA-B27 and spondyloarthropathy may be related to antigen-presenting specificity, but a different mechanism, presentation of a B27-derived peptide by class II antigens, may contribute to the pathogenesis of acute anterior uveitis, emphasizing the need for a comprehensive understanding of the structure, antigenicity, and function of HLA-B27.

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AnimalsArthritisArthritis, ReactiveAutoantigensEpitopesHLA-B27 AntigenHumansMicePolymorphism, GeneticProtein BindingT-LymphocytesJournal ArticleResearch Support, Non-U.S. Gov't

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J A López de Castro. 1995. Structural polymorphism and function of HLA-B27.. https://doi.org/10.1097/00002281-199507000-00002

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