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PubMed · 7574801

[Cell cycle regulation by anticancer agent].

T Nomoto·K Nishio·N Saijo
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Abstract

Some anticancer agents induce cell cycle arrest. We analyzed the effect of anticancer agents on cell-cycle regulators, such as CDK. Our data suggested that arresting cells in the G2-phase of the cell cycle by cisplatin might be regulated by dephosphorylation of cdc2 kinase. Butyrolactone I inhibits both cdc2 and CDK2 kinase in the cell-free system. The cytotoxic effect of paclitaxel shows mainly in the M-phase of the cell cycle. Suramin inhibits cdc2 kinase. UCN-01, a protein kinase-C inhibitor, also inhibits both cdc2 and CDK2 kinase. Some anticancer agents induce apoptosis.

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Antineoplastic AgentsAntineoplastic Agents, PhytogenicApoptosisCell CycleCell-Free SystemCisplatinCyclin-Dependent KinasesG2 PhaseHumansPaclitaxelSuraminEnglish AbstractJournal ArticleReview

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BibTeXRIS

T Nomoto, K Nishio, N Saijo. 1995. [Cell cycle regulation by anticancer agent].. https://pubmed.ncbi.nlm.nih.gov/7574801/

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